… substitution can be used to solve problems unique to the CNS, such as blood brain barrier
(… -invasive imaging and diagnoses in the CNS. In this review, fluorine in CNS drugs and drug …

… fluorinated molecules as drugs and imaging agents for CNS … Incorporating a fluorine atom
into the structure of a drug … –brain barrier permeability, which is a critical matter for drugs …

… Brain imaging using PET is one of the important new tools in … s disease, the devastating brain
disorder of elderly humans. A … active drug components, there are more than 150 fluorinated …

… In contrast, F atoms are not present in all drugs, and therefore a potent fluorine containing
drug has to be … This report is focusing on fluorinated PET tracers for imaging of σ 1 receptors . …

… and central nervous system drugs [… -[18F] fluoro substitution of 17β-estradiol allows the C-16
fluorine to function as a radiolabel and metabolism suppressor in a prototype imaging agent […

… fluorine can have dramatic effects on the drug-like properties of compounds. The presence
of this one atom can influence metabolic stability, brain … Not all effects of fluorine addition are …

… Fluorine imparts desirable characteristics to drugs by modulating both the pharmacokinetics
and pharmacodynamic properties of a drug. … of brain kinetics in PET studies. In this case, the …

… use of fluorine-18-labeled radiotracers in PET for diagnostic imaging of the brain, heart and
… anti-inflammatory agents), CNS medications and anticancer drugs. The combination of these …

… drugs for AD is the blood–brain barrier (BBB). A combination of nanotechnology with fluorinated
molecules … conducted on fluorine-containing compounds and fluorinated nanoparticles (…

… fluorine-18 and proved to be PET imaging agents for the diagnosis of cancer (101, 102). The
importance of molecular imaging … is the high brain enzyme density (V T ) with scan duration …